Abstract: Results of PCP are well known in lupus nephritis. We present here it’s outcome in patients with WHO type IV lupus nephritis, treated before the occurrence of renal failure. Patients having a follow up of more than 36 months were selected for this study. 29 patients fulfilled the selection criteria. Proteinuria, hematuria, leucocyturia, cast, BUN, creatinine and blood pressure were measured before PCP and after each one. The first and ...
Abstract: Systemic Lupus Erythematosus is not rare in Iran. We have seen 220 cases in children in a population of 893 SLE in the past 16 years. In this study we show the features of SLE in children. The female to male ratio was 86/14. Fever was present in 72% of the patients, weight loss in 40%, malar rash in 72.5%, photosensitivity in 54%, mucosal lesion in 48%, discoid rash in ...
Abstract: Systemic Lupus Erythematosus (SLE) is a known underlying disease predisposing to salmonellosis. We report here 39 cases of salmonellosis in 30 patients in a population of 897 patients with SLE, during a 17 years period. All were women with a mean age of 25.7 years. Eighty percent were taking prednisolone and 26% cytotoxics at the onset of the infection. Renal involvement was present in 77% (type IV WHO in 65% ...
Abstract: In a study on 391 cases of BD presented to the EULAR Congress in 1987 we demonstrated that the following symptoms were seen more frequently in patients with positive pathergy phenomenon: oral aphthosis as the initial manifestation of the disease, genital ulcerations, pseudofolliculitis, and arthralgia. The following symptoms, on the contrary were seen less frequently: oral aphthosis, ankylosing spondylitis. It was interesting to look after those findings, 6 years later, in ...
Abstract: Behcet Disease (BD) is known to involve nervous system. In order to evaluate the prevalence of neurological complications as early manifestations of BD, and to determine their value as indicators of the disease, we conducted a prospective study on 261 consecutive patients reffered to our BD clinic (100 control subjects and 161 BD patients), including a Questionaire about neurological symptoms, complete physical (neruological) examination, and paraclinicalstudies, No definite (significant) difference ...
Abstract: Pulse cyclophosphamide (PCP) is the most effective and the least toxic treatment in posterior uveitis (pU) and/or retinal vasculitis (RV) of Behcet's disease (BD). Conventional doses (1 g/m2) may be associated with minor side effects such as hair loss, nausea and vomiting. To find whether lower doses, such as those already employed in Lupus nephritis should be useful, we administered IVLDP (0.5 g/m2/month) plus prednisolone (0.5 mg/kg/day) to 40 BD ...
Abstract: There are 5 major sets of diagnosis criteria for BD: Mason & Barnes, O'Duffy, Dilsen, Japan revised criteria, and the International criteria (the latest one). To evaluate their accuracy we analysed their sensitivity and specificity in 2069 BD and 1519 control patients. The accuracy was calculated by the sum of BD patients fulfilling the criteria and the control patients correctly classified as non BD, divided by the sum of the ...
Abstract: Fifty-seven patients suffering from systemic lupus erythematosus with different clinical features were studied from various aspects of immunological abnormalities, including anti-nuclear antibodies; anti-DNA; anti-Sm (Smith's antigen); and, other extractable nuclear antigens. The tests employed were microhemagglutination, counter immunoelecterphoresis, and radio immunoassay (RIA). The comparison between the two techniques for detectiong anti-DNA titers showed a significant correlation between them. There was also a significant positive correlation between the presence of anti-DNA and lupus nephritis ...
Abstract: It is accepted today that cytotoxic drugs are the only remittent agents in posterior uveitis (PU) and retinal vasculitis (RV) of Behcet's disease (BD). The important question is which cytotoxic is the most effective and the least harmful. We compare here the results of 3 efficient methods of cytotoxic therapy with the same mean follow-up time of 12 months: I.V. Pulse Cyclophosphamide (PCP) in 121 patients, weekly low dose Methotrexate ...
Abstract: Antimalarials are among the most important disease modifying drugs used in Rheumatology. The major problem with them is their effects on eyes. We have done a retrospective study on 1598 patients with RA and SLE using Chloroquine for 1 month to 16 years (Mean 41 months). Eye problems was detected in 330 patients (20.6%). We found corneal deposition in 205 (13%) that was graded as severe (11%), moderate (12%) and ...