Abstract: Introduction: methotrexate in weekly low dose pulse of 7.5 mg has long proved its efficacy in the treatment of ocular lesions. During the 1998 ACR congress where we presented our data on 262 patients it was suggested the high dose of 15 mg. This is the short-term result of that study. Materials and Methods: MTX was used as 15 mg weekly. Prednisolone was associated as 0.5 mg/kg/ daily. The visual ...
Abstract: Objectives: Joint Hyper-Mobility is an important and occult joint involvement in normal population. We studied to determine the prevalence and features of JHM in Iranian students. Methods: A group of Iranian primary to high school students in Tehran was considered in the figure of a cross sectional-descriptive study. Though validated Carter-Wilkinson & Beighton criteria 997 students from five geographical regions were screened. Sampling method was Randomized - multi process. We had ...
Abstract: Objectives: The aim of this study is to analyze the clinical features, laboratory findings and type of treatments in late onset SLE (after 50 years) in Iranian patients and compare them with the early onset. Methods: Records of 1419 SLE patients who attended our lupus unit, between 1975 and 1999 were reviewed. Nineteen Patients with late onset disease were identified. For comparison, 47 patients with disease onset before the age of ...
Abstract: INTRODUCTION : Ocular manifestations are one of the main features of Behcet’s Disease. They occur in more than half the patients. In our series they were seen in 58% of cases1. The natural course of Ocular manifestations, like other manifestations of Behcet's Disease, is a progression by repetitive attacks followed by remission. However, on the contrary of other lesions (muco-cutaneous) the remission is much slower in posterior uveitis, and practically absent ...
Abstract: Muco-cutaneous lesions are the most important signs in the diagnostic criteria of Behcet’s Disease (BD), but they are not specific and can be seen in other disease too. Mucous Membrane Lesions: 1- Recurrent oral aphthosis is the most frequent lesion of BD (96.1%0.6). It was divided in major, minor, and herpetiforme aphtosis. There are also Punctiform, Miliaria, and giant aphthosis. The shape and the size of aphthae can vary ...
Abstract: Background: Our purpose was to show different aspects of the muco-cutaneous lesions of Behcet’s disease (BD). Although they are not specific, they constitute the major symptoms in all sets of diagnosis criteria for BD. Methods: Description of muco-cutaneous lesions seen during 12 years follow up in 4605 patients. Results: 1- Mucous-membrane lesions: Recurrent oral aphthosis (OA) is the most important and frequent lesion of BD. It resembles the other OA of other ...
Abstract: The chronic macular edema, frequent in ocular Behcet's disease, is a treat to the visual outcome of the patients. We have investigated the origin, risk-factors and the outcome of macular edema in patents under immunosuppressors and corticosteroid therapy. This is a retrospective, case series study. In 1999,seventeen patients of the Behcet's clinic of Shariati hospital of Tehran who had macular edema were consecutively selected and included in the study. They were ...
Abstract: Introduction: Ocular lesions of Behcet’s disease (BD) progress by recurrent attacks and remission. Their natural history, without treatment, is toward severe loss of vision or blindness. We presented last year a work to the ACR meeting on the long-term outcome of visual acuity (VA) in BD. The data showed that the final VA was related to the baseline VA (before the treatment), suggesting that a delay in aggressive treatment may ...
Abstract: Introduction: Pathergy test (PAT) is used in the majority of diagnosis criteria set for Behcet’s Disease (BD). The modality of performing it (needle gauge, sharpness of the tip, direction of skin penetration, with or without a product injection), the delay to read the result (24 or 48 hours), and the cut-off line for positive test is not standardized. Therefore the results differ from one center to another, introducing a great ...
Abstract: Background: The gene effect in pathogenesis of Rheumatic Diseases is well known, but the exact mode of transmission is not clear. In this report we present similar diseases occurred in two generations and in siblings. Methods: We overviewed the medical charts of second member of the family, according to the family history of the index patient. Results: Family I: Discoid Lupus was diagnosed in an eight years old girl whose father had ...