Abstract: Introduction: Behcet's disease (BD) is characterized by recurrent attacks followed by remissions, making difficult the assessment of a given treatment. The aim of this study was to compare the Iran Behcet's Disease Dynamic Activity Measure (IBDDAM) with the physician's global assessment (PGA) in evaluating the treatment result. Materials & Methods: Ninety-six patients with BD were followed prospectively, regardless of their treatment modality. The range of follow up was 3 to 62 ...
Abstract: Introduction: There is considerable controversy in the characteristics of Behect's disease (BD) in children. The aim of this study is to show Iran's view m juvenile BD. Materials & Methods: Different manifestations of the disease were determined in the BD patients under the age of 16. They were compared with the adult patients by chi square test. Results: We had 102 children with BD. The male/female ratio was 1.04. Oral aphthosis (64%) ...
Abstract: Increased thyroid hormones level is associated with diminished bone density. It has been clarified that thyroid hormones by sirculating bone resorption lead to decrease in bone density. Thyroid hormone in many cases as in Non - Toxic Grotre & in supplement therapy in hypothyroidism is used as a drug & it is possible that suppressive therapy with T4 causes subclinical - hyperthyroidism. Studies done in west has shown different results ...
Abstract: The outcome of ocular manifestations of Behcet’s Disease remains uncertain and unpredictable despite cytotxic drugs. One of our recent studies, presented to the 1995 Korean Rheumatology Annual Meeting, showed that one third of patients were None Responders, regardless of what treatment used. This study was designed to search for factors predicting the final outcome at the beginning of the treatment. Patients having more than one year of treatment were selected ...
Abstract: Genetic Background: Behcet’s Disease (BD) is known t0 be associated with the HLA-B5 gene. The association is with the B51subtype, the B*5101allele. The tryptophan amino acid in position 167 and histidine in position 171 seems to determine the susceptibility of B51 for BD. However all persons with B51 do not have BD and all BD patients do not have B51. Some particularity in the TNFβ gene region in BD patients ...
Abstract: The pathergy phenomenon (PP) is one of the hallmarks of Behcet's Disease (BD). It has been reported to be positive from 17.5% to 83% of cases in different studies. PP is used as a diagnosis criterion in the Dilsen criteria, the Japan criteria, the International criteria, and the Iran criteria. It is therefore important to know wether PP is a fix manifestation of the disease or a cyclic manifestation ...
Abstract: INTRODUCTION: The pathergy phenomenon (PP) is one of the hallmarks of Behcet's Disease (BD). It has been reported to be positive from 17.5% to 83% of cases in different studies. PP is used as a diagnosis criterion in the Dilsen criteria, the Japan criteria, the International criteria, and the Iran criteria. It is therefore important to know whether PP is a fix manifestation of the disease or a cyclic manifestation ...
Abstract: Introduction: Prolactin (PRL) is an immune stimulating hormone and may be important in the pathogenesis of some autoimmune diseases, such as SLE. This study was designed to detect the PRL level in patients with Behcet's disease (BD), and its relation to the different manifestations of the disease. Materials & Methods: Thirty-seven new male patients with BD and 29 age matched control normal individuals (CON) was selected as every consecutive patient. The ...
Abstract: Behcet’s Unite, Shariati Hospital the aim to propose a scoring system for the treatment of the ocular inflammation one vasculitis by our medications and to evaluate the state of the activity of the eye. Eleven activity and five chronicity (constant) parameters are scored from zero to four to consider the condition of each eye. The activity variables are: episcleritis &/or scleritis, anterior uveitis, hyalites, IMU, central periphlebitis &/or thrombosis, central periartertis, peripheral ...
Abstract: Introduction: Opthalmologic manifestations are the major cause of morbidity in Behcet’s Disease. If not treated, they usually progress toward sever loss of vision or blindness. Cytotoxic drugs are the main therapeutic agents. Materials & Methods: In an open, non randomized, control study, pulse cyclophosphamide (PCP), low dose pulse cyclophosphamide (LDP), weakly methtrexate (MTX), chlorambucil (CHL), oral cyclophosphamide (OCP), and cyclosporine A (CYA) were used in a standard protocol for 778 patients. ...