Abstract: Objectives: Behcet's disease (BD) is a multi-system disease. We present here the various clinical aspects of BD based on the data of 4586 Iranian patients. The male to female ratio was 1.17/l. The mean age at the onset of the disease was 26 yr (SD:9.6, CI:0.3). The mean disease duration was 9 yr (SD:7), and the mean follow up time was 3 yr (SD:3.8). As the first manifestation of the ...
Abstract: Introduction: Oxygen free radicals that are generated mainly through the phagocytic activity of the polymorphonuclear leucocytea have been implicated as mediators of tissue damage in patients with rheumatoid arthritis (RA). Accordingly low levels of antioxidants, which increase free radical activity, are clearly associated with an increased risk of RA. Methods: Of 24 patients who entered the study 14 patients were excluded because they failed regular follow up. The analysis was ...
Abstract: Pattern of Rheumatic Diseases in Iran: They have the same frequency and the same pattern as in Western countries. A study from 1993 demonstrated a prevalence of 32.6% among adults (31.4% in the USA, Cunningham 1984). Inflammatory disorders counted for 11% of all rheumatic diseases. The ratio of RA to AS was 8/1 (7/1 in USA), and SLE to Scleroderma 3.5/1 (3.6/1 in USA). Psoriatic arthritis and Reiter's syndrome were ...
Abstract: Introduction: Behcet's Disease (BD) is characterized by recurrent attacks and remissions, making difficult the assessment of the treatment's result. Moreover, the remission period between the attacks is not the same and may vary from one attack to another. The attack periods are not always the same and may vary in severity, or extent of organ involvement. Iran Behcet's Disease Dynamic Activity Measure (IBDDAM) takes in account all of these parameters ...
Abstract: Objectives: The etiology and pathogenesis of Behcet's disease (BD) are still unknown. It seems that in a special genetic background exogenous or endogenous antigen(s) acts as trigger in up regulating and presenting the pathogenic epitope. The immune system reacts in an abnormal way, by inducing a cascade of cytokines and chemokines to stimulate innate immune responses, leading to the lesions of the disease. Genetic background: The major susceptibility gene is the ...
Abstract: Introduction: Large vessel involvement is one of the hallmarks of Behcet's disease (BD). Like the other manifestations of the disease, its prevalence differs due to ethnic variation and environmental factors. The aim of this study is to find the characteristics of vasculo Behcet in Iran. Materials & Methods: In a cohort of 4429 patients with BD, those with vascular involvement were selected (VB). Different manifestations of the disease were compared with ...
Abstract: INTRODUCTION: The natural history of ocular lesions in Behcet's Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to ...
Abstract: INTRODUCTION: The natural history of ocular lesions Behcet’s Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to address ...
Abstract: Background: Cardiac involvement is not a common feature of Behcet's disease (BD), but may be a sign for poor prognosis. There are only few case reports in the literature and the prevalence of cardiac involvement in BD is not exactly known. Our study was designed to find the prevalence and characteristics of cardiac involvement in Iranian patients with BD. Methods: All new cases referred to Behcet's clinic ...
Abstract: Objectives: The ocular manifestations of Behcet's disease (BD) are very frequent involving approximately 60% of BD patients. These lesions consist mainly of uveitis (anterior, posterior, or panuveitis that are present in almost all the BD patients with ocular involvement) and necrotizing vasculitis of the retina. In a randomized survey carried on 1812 patients with Ocular-Behcet the prevalence of different ocular signs were as follow: Hypopion 8.7%, glaucoma 8.5%, cataract 70%, ...