Abstract: In a study on 391 cases of BD presented to the EULAR Congress in 1987 we demonstrated that the following symptoms were seen more frequently in patients with positive pathergy phenomenon: oral aphthosis as the initial manifestation of the disease, genital ulcerations, pseudofolliculitis, and arthralgia. The following symptoms, on the contrary were seen less frequently: oral aphthosis, ankylosing spondylitis. It was interesting to look after those findings, 6 years later, in ...
Low dose pulse cyclophosphamide (LDP) in ophthalmological lesions of Behget's disease.
Abstract: Pulse cyclophosphamide (PCP) is the most effective and the least toxic treatment in posterior uveitis (pU) and/or retinal vasculitis (RV) of Behcet's disease (BD). Conventional doses (1 g/m2) may be associated with minor side effects such as hair loss, nausea and vomiting. To find whether lower doses, such as those already employed in Lupus nephritis should be useful, we administered IVLDP (0.5 g/m2/month) plus prednisolone (0.5 mg/kg/day) to 40 BD ...
Accuracy of existing diagnosis criteria for Behcet's disease (BD).
Abstract: There are 5 major sets of diagnosis criteria for BD: Mason & Barnes, O'Duffy, Dilsen, Japan revised criteria, and the International criteria (the latest one). To evaluate their accuracy we analysed their sensitivity and specificity in 2069 BD and 1519 control patients. The accuracy was calculated by the sum of BD patients fulfilling the criteria and the control patients correctly classified as non BD, divided by the sum of the ...
Comparing 3 methods of cytotoxic therapy in ophthalmologic lesions of Behcet's disease.
Abstract: It is accepted today that cytotoxic drugs are the only remittent agents in posterior uveitis (PU) and retinal vasculitis (RV) of Behcet's disease (BD). The important question is which cytotoxic is the most effective and the least harmful. We compare here the results of 3 efficient methods of cytotoxic therapy with the same mean follow-up time of 12 months: I.V. Pulse Cyclophosphamide (PCP) in 121 patients, weekly low dose Methotrexate ...
Classification tree for the diagnosis of Behcet's disease (BD).
Abstract: The diagnosis method by Classification And Regression Tree (CART) is gaining more importance every year, specially in Rheumatology by the efforts of the American College of Rheumatology. The classification tree not only provides an accurate tool for diagnosis, it gives a better insight of the manifestations of the disease and the value of different criteria for the diagnosis. In this study we analyzed 1992 Behcet's patients (BP) and 1506 control ...
Behcet's disease in children.
Abstract: Behcet's disease (BD) is not rare in children, and it's clinical picture differs from that in adults. We studied 66 patients in whom the disease was diagnosed under the age 16 from a population of 2068 BD patients. Comparison of the results with the adults by the student paired t test showed: although the most frequent initial manifestation of BD in children was oral aphthosis (54.5%), it was less frequent ...
Clinical manifestations of Behcet's disease in Iran. Analysis of 2068 cases.
Abstract: The annual incidence of Behcet's Disease (BD) is as high as 300 patients per year. The mean age at the onset of the first symptom is 26.7 years (SD = 9.7). The sex distribution is 54% male and 46% female. The initial manifestation was mainly oral aphthosis (73%), uveitis (13%), genital ulcerations (11%), arthritis (9%), and skin manifestations (9%). Clinical manifestations were as fallow: mucous membrane manifestations were seen in 95.5% ...
Audio vestibular involvement in Behcet's disease (BD).
Abstract: There is only three reports on the frequency of audio vestibular involvement in BD in the literature. In these studies, done in small population of BD patients, the frequency of auditory involvement were reported as high as 60%, and the vestibular involvement between 25 to 37%. We studied prospectively the audio vestibular involvement in 80 patients with BD, and compared them with 102 controls (CG) including hospital staffs, patients with ...