Abstract: Fifty-seven patients suffering from systemic lupus erythematosus with different clinical features were studied from various aspects of immunological abnormalities, including anti-nuclear antibodies; anti-DNA; anti-Sm (Smith's antigen); and, other extractable nuclear antigens. The tests employed were microhemagglutination, counter immunoelecterphoresis, and radio immunoassay (RIA). The comparison between the two techniques for detectiong anti-DNA titers showed a significant correlation between them. There was also a significant positive correlation between the presence of anti-DNA and lupus nephritis ...