Abstract: The prognosis of Lupus Nephritis has dramatically changed since the introduction of cytotoxic drugs in their treatment. Different protocols have been proposed to reach this goal. Pulse cyclophosphamide (PCP) was first introduced in the treatment of Systemic Lupus Erythematosus by Sessoms & Kovarsky in 1984. Austin and Colleagues demonstrated it's superiority upon other regimens in Lupus Nephritis in 1986. Pulse Cyclophosphamide is now a well established method for the treatment ...