Abstract: It is accepted today that cytotoxic drugs are the only remittent agents in posterior uveitis (PU) and retinal vasculitis (RV) of Behcet's disease (BD). The important question is which cytotoxic is the most effective and the least harmful. We compare here the results of 3 efficient methods of cytotoxic therapy with the same mean follow-up time of 12 months: I.V. Pulse Cyclophosphamide (PCP) in 121 patients, weekly low dose Methotrexate ...
Classification tree for the diagnosis of Behcet's disease (BD).
Abstract: The diagnosis method by Classification And Regression Tree (CART) is gaining more importance every year, specially in Rheumatology by the efforts of the American College of Rheumatology. The classification tree not only provides an accurate tool for diagnosis, it gives a better insight of the manifestations of the disease and the value of different criteria for the diagnosis. In this study we analyzed 1992 Behcet's patients (BP) and 1506 control ...
OPHTHALMOLOGIC SIDE EFFECTS OF CHLOROQUINE, ANALYSIS IN 1598 PATIENTS WITH RHEUMATlC DISEASES.
Abstract: Antimalarials are among the most important disease modifying drugs used in Rheumatology. The major problem with them is their effects on eyes. We have done a retrospective study on 1598 patients with RA and SLE using Chloroquine for 1 month to 16 years (Mean 41 months). Eye problems was detected in 330 patients (20.6%). We found corneal deposition in 205 (13%) that was graded as severe (11%), moderate (12%) and ...
CHILBLAIN LUPUS ERYTHEMATOSUS IN A MONOLYGOTE TWIN.
Abstract: CHILBLAIN LUPUS ERYTHEMATOSUS IN A MONOLYGOTE TWIN.#C. Chams, M. Akbarian, P. Mansoori, F. Shahram, and F. Davatchi#Revista Espanola de Reumatologia, 1993; 20 (Suppl 1): p. 358 #Chilblain lupus erythematosus or lupus pernio was described by HUTCHINSON in 1888. Even actually it is difficult to put this entity in a well defined nosologic place as systemic lupus erythematosus. We report here the case of a twin monozygote brothers of 11 years old, ...
Behcet's disease in children.
Abstract: Behcet's disease (BD) is not rare in children, and it's clinical picture differs from that in adults. We studied 66 patients in whom the disease was diagnosed under the age 16 from a population of 2068 BD patients. Comparison of the results with the adults by the student paired t test showed: although the most frequent initial manifestation of BD in children was oral aphthosis (54.5%), it was less frequent ...
Clinical manifestations of Behcet's disease in Iran. Analysis of 2068 cases.
Abstract: The annual incidence of Behcet's Disease (BD) is as high as 300 patients per year. The mean age at the onset of the first symptom is 26.7 years (SD = 9.7). The sex distribution is 54% male and 46% female. The initial manifestation was mainly oral aphthosis (73%), uveitis (13%), genital ulcerations (11%), arthritis (9%), and skin manifestations (9%). Clinical manifestations were as fallow: mucous membrane manifestations were seen in 95.5% ...
Audio vestibular involvement in Behcet's disease (BD).
Abstract: There is only three reports on the frequency of audio vestibular involvement in BD in the literature. In these studies, done in small population of BD patients, the frequency of auditory involvement were reported as high as 60%, and the vestibular involvement between 25 to 37%. We studied prospectively the audio vestibular involvement in 80 patients with BD, and compared them with 102 controls (CG) including hospital staffs, patients with ...
Long-term outcome of pulse cyclophosphamide (PCP) in Behcet's disease (BD) ocular lesions.
Abstract: Since our first report in 1987 to the 11th EULAR congress of rheumatology several reports had shown the efficacy of PCP in posterior uveitis (PU) and retinal vasculitis (RV) of BD. The aim of this report is to show the safety and the efficacy of PCP even in patients who have been followed for more than 2 years (49 cases) . PCP was given as 1g/m2/body surface, once per month, ...
Lupus Nephritis in Iran. Analysis of 287 cases.
Abstract: Systemic Lupus Erythematosus (SLE) is a rather frequent disease in Iran. In the past 13 years, 449 patients with SLE attended the SLE clinic. Lupus nephritis was discovered in 278 of them. The purpose of this study is to demonstrate the caracteristics of lupus nephritis in Iran (percentage of proteinuria, hematuria, leucocyturia, casts, renal insufficiency, hypertension, and patterns of renal biopsy), to compare them to the remaining patients with SLE ...
Weekly low-dose pulsed methotrexate in ocular Behcet (analysis of 41 cases).
Abstract: Cytotoxic drugs as the only remittent agents in posterior uveitis (PU) and/or retinal vasculitis (RV) of Aehcet's disease(BD) is generally accepted today. However which cytotoxic is the least harmful and yet efficient is questionable. The safety of long term use of MTX in rheumatoid arthritis made us to use this drug in ocular Behcet. Our prelimi-nary report to the first APLAR Symposium for Treatment of Rheumatic Diseases in Korea, stowed ...