Abstract: Introduction: Behcet's Disease (BD) is characterized by recurrent attacks and remissions, making difficult the assessment of the treatment's result. Moreover, the remission period between the attacks is not the same and may vary from one attack to another. The attack periods are not always the same and may vary in severity, or extent of organ involvement. Iran Behcet's Disease Dynamic Activity Measure (IBDDAM) takes in account all of these parameters ...
Immunopathogenesis Of Behcet's Disease.
Abstract: Objectives: The etiology and pathogenesis of Behcet's disease (BD) are still unknown. It seems that in a special genetic background exogenous or endogenous antigen(s) acts as trigger in up regulating and presenting the pathogenic epitope. The immune system reacts in an abnormal way, by inducing a cascade of cytokines and chemokines to stimulate innate immune responses, leading to the lesions of the disease. Genetic background: The major susceptibility gene is the ...
LARGE VESSEL MANIFESTATIONS OF BEHCET’S DISEASE,REPORT OF 377 CASES.
Abstract: Introduction: Large vessel involvement is one of the hallmarks of Behcet's disease (BD). Like the other manifestations of the disease, its prevalence differs due to ethnic variation and environmental factors. The aim of this study is to find the characteristics of vasculo Behcet in Iran. Materials & Methods: In a cohort of 4429 patients with BD, those with vascular involvement were selected (VB). Different manifestations of the disease were compared with ...
LONG-TERM OUTCOME OF VISION IN BEHCET'S DISEASE.
Abstract: INTRODUCTION: The natural history of ocular lesions in Behcet's Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to ...
LONG-TERM OUTCOME OF VISION IN BEHCET’S DISEASE.
Abstract: INTRODUCTION: The natural history of ocular lesions Behcet’s Disease (BD) is gradual progressions of lesions toward severe loss of vision or blindness. The association of cytotoxic drugs and steroids has dramatically changed the outcome. However, some authors still believe that the improvement is temporary and in the long run (10 years) the eyes progress toward blindness no matter what treatment was applied. The aim of this study was to address ...
Cardiac Involvement in Behcet's Disease, A Case Control Study.
Abstract: Background: Cardiac involvement is not a common feature of Behcet's disease (BD), but may be a sign for poor prognosis. There are only few case reports in the literature and the prevalence of cardiac involvement in BD is not exactly known. Our study was designed to find the prevalence and characteristics of cardiac involvement in Iranian patients with BD. Methods: All new cases referred to Behcet's clinic ...
Ocular Lesions Of Behcet's Disease.
Abstract: Objectives: The ocular manifestations of Behcet's disease (BD) are very frequent involving approximately 60% of BD patients. These lesions consist mainly of uveitis (anterior, posterior, or panuveitis that are present in almost all the BD patients with ocular involvement) and necrotizing vasculitis of the retina. In a randomized survey carried on 1812 patients with Ocular-Behcet the prevalence of different ocular signs were as follow: Hypopion 8.7%, glaucoma 8.5%, cataract 70%, ...
SACROILIITIS IN BEHCET'S DISEASE, A RADIOLOGIC STUDY.
Abstract: Introduction: The association of Behcet's disease (BD) and ankylosing spondylitis (AS) is still a controversial subject. As the presence of sacroiliac joint (SIJ) involvement is an essential criterion in the diagnosis of AS, we decided to determine the prevalence of SIJ involvement in BD and compare it with control group. Materials & Methods: We selected randomly 199 BD patients and 168 non-BD cases (CG), in a 12 month period (between April ...
Treatment of Ocular Lesions of Behcet’s Disease.
Abstract: Purpose: Cytotoxic drugs are the main therapeutic agents. A comparative study of 8 different therapeutic methods in 1220 cases is presented here. Materials & Methods: In an open, non-randomized control study, Pulse Cyclophosphamide (PCP), low dose PCP (LDP), oral cyclophosphamide ( OCP), weakly methotrexate ( MTX), chlorambucil ( CHL), cyclosporine A ( CYA), azathioprine (AZA), and combination therapy with LDP and MTX (COM) were used. Mean Duration: Ocular manifestations in months. FU: ...
Is acne vulgaris seen more often in Behcet Disease than in the normal population?
Abstract: Background: In the literature, some of the skin pustular lesions of BD resembling the pustular lesion of acne vulgaris (AV) was called acneiform lesion of BD. It was suggested that AV was seen more often in BD than in normal population. AV is a common and very frequent skin lesion. The lesions are polymorphic, and are noninflamed (closed or open comedones) or inflamed (papules, pustules, nodules). Objectives: To find if ...