Abstract: Neuropsychiatric manifestations of SLE are frequent and usually serious, convulsion is one of the most important and hazardous symptoms of CNS-LUPUS. Because there are many differences in clinical manifestations frequency and severity of organ systems involvement, and cause of death in patients with SLE (in Iran and other countries) an analytic retrospective case-control study was carried out to evaluate the frequency of convulsion in relation with age and sex distribution, ...