Abstract: The prognosis of Systemic Lupus Erythematosus depends partly on renal involvement. Lupus nephritis has evolved from a frequently terminal process such as type IV lupus nephritis according to WHO classification to one in which a fairly normal quality of life and good outcome are possible. The aim of this study was to try to predict the short-term outcome of type IV lupus nephritis by looking at the disease variables before ...
On going epidemiological survey on Behcet's Disease in Iran; Tendency toward milder forms of the disease.
Abstract: Introduction: Iran is among the countries with high prevalence of Behcet's Disease (BD). The epidemiological survey on different aspects of the disease has been continuously carrying out since 1975 in our center. The aim of this study was to find if the characteristics of the disease are changing through the time. Patients & Methods: In a cohort of 4130 patients with BD, registered at our BD unit during the past 25 ...
Long-term outcome of ocular manifestations in Behcet's Disease.
Abstract: Introduction: The natural history of ocular manifestations is very poor in Behcet's Disease (BD). The lesions progress by successive attacks leading to sever loss of vision or blindness. Aggressive treatments, by the association of cytotoxic drugs and steroids, have dramatically changed the outcome. However, still some ophthalmologists are convinced that the improvement is temporary and in the long run the eyes progress toward blindness. The aim of this study was ...
COMPARISON OF POLYMYOSITIS TO POLYMYOSITIS-SCLERODERMA OVERLAP SYNDROME.
Abstract: Purpose: Polymyositis (PM) is an inflammatory muscle disease, which has more overlap with scleroderma than other connective tissue diseases. The aim of this study is to compare the clinical, paraclinical and therapeutic response of polymyositis with polymyositis-scleroderma overlap syndrome. Methods: During the past 10 years we had 16 overlap syndromes and 40 primary polymyositis. All patients were classified by the American college of Rheumatology classification criteria. Ninety-seven items were checked in ...
Azathioprine for The Treatment of Ophthalmological Lesions of Behcet’s Disease.
Abstract: Introduction: Posterior uveitis (PU) and retinal vasculitis (RV) are the main morbidity factor in Behcet’s Disease (BD). They usually progress toward severe loss of vision or blindness. They need aggressive treatment with cytotoxic drugs. Azathioprine was demonstrated, in a double blind control study, to be effective in Behcet’s Disease. The aim of this study was to evaluate the efficacy of Azathioprine in ocular lesions of BD, and to compare ...
Comparison of Juvenile wth Adult Behcet’s Disease.
Abstract: Introduction: Behcet’s disease (BD) is not rare in children. Its clinical picture differs from adults. The purpose of this study was 1-To find the characteristics of juvenile BD (JBD). 2-To compare JBD with the adult from (ABD) of the disease. Materials & Methods: In a cohort of 3729 patients with BD, different manifestations of the disease, including 100 clinical and paraclinical data, were analyzed. Patients were divided in two groups. 1- ...
Familial Oral Aphthosis in General Population As Compared To Behcet’s Disease.
Abstract: Introduction: Oral aphthosis (OA) is seen in 96% of patient with Behcet’s Disease (BB) OA is said to be rather frequent in the general population. It was therefore interesting to determine whether OA in the general population had also a genetic background as it is for BD. It was also interesting to determine if the genetic background was similar in both conditions (BD and OA in the general population). Therefore, ...
METHOTREXATE FOR OCULAR LESIONS OF BEHCET'S DISEASE. COHORT STUDY ON 262 PATIENTS.
Abstract: INTRODUCTION: Ocular lesions of Behcet's Disease (BD) progress usually toward severe loss of vision or blindness, if not aggressively treated. Cytotoxic drugs are the main therapeutic arsenals used for it: Low dose methotrexate (MTX) by its safety and its efficacy is one of the best therapeutic choices. MATERIALS &METHODS: MTX was used as 7.5 mg weekly. Prednisolone was associated as 0.5 mg/kg/ daily. Upon the suppression of the inflammatory reaction, prednisolone ...
Pulse Cyclophosphamide for ocular Manifestations of Behcet's Disease. Cohort study on 283 patients.
Abstract: Introduction: Posterior uveitis (PU) and retinal vasculitis (RV) usually progress toward severe loss of vision or blindness, if not aggressively treated. The aim of this study is to evaluate the efficacy of Pulse Cyclophosphamide (PCP) in a cohort study. Methods: This study includes all patients treated with PCP from 1986 to 1998, for active PU and or RV. PCP was administered as Ig cvclophosphamide/m2/body surface, once per month. Prednisolone was given ...
Does spondyloarthropathy Seen in Behcet’s Disease (BD) Change The Features Of BD?
Abstract: INTRODUCTION: BD has been reported to be associated with ankylosing .spondylitis (AS) in many cases. We observed spondyloarthropathy (SpA) in our Behcet's patients more than in the normal population of Iran which is 0.18% (p